WEHI-345

Overview
Catalog #	bs-6579c-10mg-solid
Product Name	WEHI-345
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 401.46 Formula: C22 H23 N7 O CAS Number: 1354825-58-3 InChi Key: LEBSTCDZKUSVOY-UHFFFAOYSA-N InChi: InChI=1S/C22H23N7O/c1-14-4-6-15(7-5-14)18-17-19(23)26-13-27-20(17)29(28-18)22(2,3)12-25-21(30)16-8-10-24-11-9-16/h4-11,13H,12H2,1-3H3,(H,25,30)(H2,23,26,27) Smiles: CC1C=CC(=CC=1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)CNC(=O)C1C=CN=CC=1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. Despite only delaying NF-κB activation on NOD stimulation, WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.