VU 0364770

Overview
Catalog #	bs-6574c-10mg-solid
Product Name	VU 0364770
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 232.67 Formula: C12 H9 Cl N2 O CAS Number: 61350-00-3 InChi Key: SUYUTNCKIOLMAJ-UHFFFAOYSA-N InChi: InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16) Smiles: O=C(NC1=CC(Cl)=CC=C1)C1C=CC=CN=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	VU0364770 is a Positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.