KN-62

Overview
Catalog #	bs-6569c-10mg-solid
Product Name	KN-62
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 721.84 Formula: C38 H35 N5 O6 S2 CAS Number: 127191-97-3 InChi Key: RJVLFQBBRSMWHX-DHUJRADRSA-N InChi: InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1 Smiles: CN([C@@H](CC1C=CC(=CC=1)OS(=O)(=O)C1=CC=CC2=CN=CC=C12)C(=O)N1CCN(CC1)C1C=CC=CC=1)S(=O)(=O)C1=CC=CC2=CN=CC=C12 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	KN62 is a P2X7R antagonist (hP2X7 IC50 = 51 nM) and Ca2+/calmodulin-dependent protein kinase II inhibitor. KN62 inhibits the invasiveness of cancer cells in vitro and in vivo KN62 causes retrograde amnesia in the rat. KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels. The effect of KN62 on Ca(2+)-influx appears to be specific to slowly-or non-inactivating conductances, and therefore presents KN62 as a potentially useful tool.