ML364

Overview
Catalog #	bs-6557c-10mg-solid
Product Name	ML364
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 517.54 Formula: C24 H18 F3 N3 O3 S2 CAS Number: 1991986-30-1 InChi Key: QZUGMNXETPARLI-UHFFFAOYSA-N InChi: InChI=1S/C24H18F3N3O3S2/c1-15-7-10-18(11-8-15)35(32,33)30-20-13-17(24(25,26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14,30H,1H3,(H,28,29,31) Smiles: CC1C=CC(=CC=1)S(=O)(=O)NC1C=C(C=CC=1C(=O)NC1=NC(=CS1)C1=CC=CC=C1)C(F)(F)F Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	ML364 is a small molecule inhibitor of the deubiquitinase USP2 with potential anticancer activity. ML364 has an IC50 of 1.1 μm in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. Direct binding of ML364 to USP2 was demonstrated using microscale thermophoresis. ML364 induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest as shown in Western blottings and flow cytometry assays utilizing both Mino and HCT116 cancer cell lines.