MERcK-5

Overview
Catalog #	bs-6539c-2mg-solid
Product Name	MERcK-5
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 309.34 Formula: C18 H16 F N3 O CAS Number: 457081-03-7 InChi Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N InChi: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22) Smiles: CC(C)(C)C1NC2C(N=1)=C1C=CNC(=O)C1=C1C=C(F)C=CC1=2 Purity: 98.0 Solubility: Soluble in DMSO, not in water. Appearance: Solid Power Shelf Life: 1.0 years
Description	Pyridone 6, also known CMP 6 or JAK Inhibitor I, is a pan-Janus-activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. Pyridone 6 induces growth inhibition of multiple myeloma cells.