KI-20227

Overview
Catalog #	bs-6532c-2mg-solid
Product Name	KI-20227
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 480.54 Formula: C24 H24 N4 O5 S CAS Number: 623142-96-1 InChi Key: SHPFDGWALWEPGS-UHFFFAOYSA-N InChi: InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) Smiles: COC1C=C2C(=CC=1OC)N=CC=C2OC1=CC(OC)=C(C=C1)NC(=O)NC(C)C1=NC=CS1 Purity: 98.0 Solubility: DMSO: 96 mg/mL(199.77 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	KI-20227 is a potent and orally active inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). KI-20227 suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. KI-20227 inhibits disease progression in a collagen-induced arthritis mouse model. KI-20227 suppresses experimental autoimmune encephalomyelitis.