AZD-2281

Overview
Catalog #	bs-6491c-2mg-solid
Product Name	AZD-2281
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 434.46 Formula: C24 H23 F N4 O3 CAS Number: 763113-22-0 InChi Key: FDLYAMZZIXQODN-UHFFFAOYSA-N InChi: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30) Smiles: O=C(C1CC1)N1CCN(CC1)C(=O)C1C=C(CC2=NNC(=O)C3=CC=CC=C23)C=CC=1F Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	AZD-2281, also known as Olaparib or KU-59436 , is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. AZD-2281 selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. AZD-2281 was approved in 2014 for treating advanced ovarian cancer.