SKLB-610

Overview
Catalog #	bs-6486c-2mg-solid
Product Name	SKLB-610
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 415.37 Formula: C21 H16 F3 N3 O3 CAS Number: 1125780-41-7 InChi Key: WACDHHMEVMSODJ-UHFFFAOYSA-N InChi: InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28) Smiles: CNC(=O)C1C=C(C=CN=1)OC1C=CC(=CC=1)NC(=O)C1=CC(=CC=C1)C(F)(F)F Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	SKLB-610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB-610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB-610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated.