EXP3174

Overview
Catalog #	bs-6459c-10mg-solid
Product Name	EXP3174
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 436.89 Formula: C22 H21 Cl N6 O2 CAS Number: 124750-92-1 InChi Key: ZEUXAIYYDDCIRX-UHFFFAOYSA-N InChi: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28) Smiles: CCCCC1=NC(Cl)=C(C(O)=O)N1CC1C=CC(=CC=1)C1C=CC=CC=1C1NN=NN=1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	EXP3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.