GNE-7915

Overview
Catalog #	bs-6422c-10mg-solid
Product Name	GNE-7915
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 443.4 Formula: C19 H21 F4 N5 O3 CAS Number: 1351761-44-8 InChi Key: XCFLWTZSJYBCPF-UHFFFAOYSA-N InChi: InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27) Smiles: COC1=CC(C(=O)N2CCOCC2)=C(F)C=C1NC1N=C(NCC)C(=CN=1)C(F)(F)F Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	GNE-7915 is a potent LRRK2 kinase inhibitor, which possess an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. GNE-7915 was reported as a potent (IC50=9 nM) selective (1/187 kinases), brain-penetrant and non-toxic inhibitor of LRRK2.