CFTR Inhibitor II(GlyH101)

Overview
Catalog #	bs-6419c-10mg-solid
Product Name	CFTR Inhibitor II(GlyH101)
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 493.15 Formula: C19 H15 Br2 N3 O3 CAS Number: 328541-79-3 InChi Key: RMBDLOATEPYBSI-NUGSKGIGSA-N InChi: InChI=1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22,26-27H,10H2,(H,24,25)/b23-9+ Smiles: OC1=C(/C=N/NC(=O)CNC2C=CC3=CC=CC=C3C=2)C=C(Br)C(O)=C1Br Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	CFTR Inhibitor II is a CFTR inhibitor (cystic fibrosis transmembrane conductance regulator). CFTR Inhibitor II is a glycine hydrazide that has been shown to block CFTR channels. CFTR Inhibitor II blocked I(Cl.PKA) in a concentration- and voltage-dependent fashion (IC(50) at +100 mV=0.3 ± 1.5 μM and at -100 mV=5.1 ± 1.3 μM). CFTR Inhibitor II blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 ± 0.03 from the external membrane surface.