LDN-214117

Overview
Catalog #	bs-6409c-2mg-solid
Product Name	LDN-214117
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 419.52 Formula: C25 H29 N3 O3 CAS Number: 1627503-67-6 InChi Key: BHUXVRVMMYAXKN-UHFFFAOYSA-N InChi: InChI=1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3 Smiles: CC1N=CC(=CC=1C1=CC(OC)=C(OC)C(=C1)OC)C1C=CC(=CC=1)N1CCNCC1 Purity: 98.0 Solubility: DMSO : ≥ 100 mg/mL (238.37 mM) Appearance: Solid Power Shelf Life: 1.0 years
Description	LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN-214117 shows a high degree of selectivity for ALK2 and low cytotoxicity that could provide a template for preclinical development.