AG-1517

Overview
Catalog #	bs-6400c-2mg-solid
Product Name	AG-1517
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 360.21 Formula: C16 H14 Br N3 O2 CAS Number: 153436-54-5 InChi Key: LSPANGZZENHZNJ-UHFFFAOYSA-N InChi: InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) Smiles: COC1C=C2C(NC3=CC(Br)=CC=C3)=NC=NC2=CC=1OC Purity: 98.0 Solubility: Soluble in DMSO, not soluble in water. Appearance: Solid Power Shelf Life: 1.0 years
Description	AG-1517 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2).