BIX-02188

Overview
Catalog #	bs-60430c-2-mg-solid
Product Name	BIX-02188
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 412.48 Formula: C25 H24 N4 O2 CAS Number: 334949-59-6 InChi Key: FSZPIAXLCCQFCM-FCQUAONHSA-N InChi: InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22- Smiles: CN(C)CC1C=C(C=CC=1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO: ≥ 45 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	BIX-02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1, 800 nM, respectively). Inhibition of MEK5 by BIX-02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.