GN44028 --- HIF-1α Inhibitor
| Overview | |
| Catalog # | bs-60325c-2-mg-solid |
| Product Name | GN44028 --- HIF-1α Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 305.33 Formula: C18 H15 N3 O2 CAS Number: 1421448-26-1 InChi Key: CGZKSZVSWAAUHE-UHFFFAOYSA-N InChi: InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21) Smiles: C1C2C(NC3=CC4OCCOC=4C=C3)=NNC=2C2=CC=CC=C21 Purity: 98.0 Solubility: DMSO up to 100 mM; EtOH up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | GN44028 is potent and selective HIF-1α inhibitor with IC50 ~14 nM. It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions. This suggests that GN44028 probably affected the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer. |
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