PF-CBP1，CBP/p300 Bromodomain Inhibitor

Overview
Catalog #	bs-60313c-2-mg-solid
Product Name	PF-CBP1，CBP/p300 Bromodomain Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 488.62 Formula: C29 H36 N4 O3 CAS Number: 1962928-21-7 InChi Key: CGWBJJZOKGZCSJ-UHFFFAOYSA-N InChi: InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3 Smiles: CCCOC1C=CC(CCC2=NC3C=C(C=CC=3N2CCN2CCOCC2)C2=C(C)ON=C2C)=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM; EtOH up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PF-CBP1 is a potent and selective CBP/p300 bromodomain inhibitor (IC50 ~125 nM for CBP and 363 nM for p300). It has >100-fold selectivity for CBP over BRD4, and shows selectivity over a panel of other bromodomains. PF-CBP1 reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. It can also downregulate RGS4 expression in primary cortical neurons in vitro.