CB-5083, p97 AAA ATPase Inhibitor

Overview
Catalog #	bs-60306c-2-mg-solid
Product Name	CB-5083, p97 AAA ATPase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 413.47 Formula: C24 H23 N5 O2 CAS Number: 1542705-92-9 InChi Key: RDALZZCKQFLGJP-UHFFFAOYSA-N InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28) Smiles: CC1=CC2C(=CC=CC=2N1C1=NC2CCOCC=2C(NCC2C=CC=CC=2)=N1)C(N)=O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer.