Hydroxychloroquine (HCQ), Autophagy and TLR9 Inhibitor

Overview
Catalog #	bs-60302c-2-mg-solid
Product Name	Hydroxychloroquine (HCQ), Autophagy and TLR9 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 433.95 Formula: C18 H28 Cl N3 O5 S CAS Number: 747-36-4 InChi Key: JCBIVZZPXRZKTI-UHFFFAOYSA-N InChi: InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4) Smiles: CCN(CCO)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C21.OS(O)(=O)=O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Hydroxychloroquine (HCQ) is a potent autophagy inhibitor and TLR9 inhibitor. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process. In cancer cells, HCQ treatment has been shown to cause increased apoptosis, tumor regression, and delay in tumor recurrence. HCQ was an effective growth inhibitor of human RCC cell lines, inhibiting growth, promoting apoptosis, and effecting cellular metabolism. HCQ altered the levels of the mTORC1 activation marker phospho-S6 and that this effect was mediated by a different mechanism than that observed for the mTOR inhibitor RAD001. HCQ is also a potent inhibitor of TLR9, prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo.