INCB024360 (Epacadostat), IDO Inhibitor

Overview
Catalog #	bs-60292c-2-mg-solid
Product Name	INCB024360 (Epacadostat), IDO Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 438.23 Formula: C11 H13 Br F N7 O4 S CAS Number: 1204669-58-8 InChi Key: FBKMWOJEPMPVTQ-UHFFFAOYSA-N InChi: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23) Smiles: NS(=O)(=O)NCCNC1=NON=C1/C(/NC1=CC(Br)=C(F)C=C1)=N/O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	INCB024360 is a potent and selective indoleamine 2, 3-dioxygenase (IDO1) inhibitor with IC50 ~10 nM It displays high selectivity over other related enzymes such as IDO2 or tryptophan 2, 3-dioxygenase (TDO). In coculture systems of human allogeneic lymphocytes with dendritic cells (DCs) or tumor cells, INCB024360 inhibition of IDO1 promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells. Administration of INCB024360 to tumor-bearing mice significantly inhibits tumor growth in a lymphocyte-dependent manner. INCB024360 has completed Phase I clinical trials and is now being used in combination with other cancer immunotherapy agents.