TZ9, Rad6 Ubiquitin Inhibitor
| Overview | |
| Catalog # | bs-60286c-10mg-solid |
| Product Name | TZ9, Rad6 Ubiquitin Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 366.33 Formula: C17 H14 N6 O4 CAS Number: 1002789-86-7 InChi Key: RRRDZFQRNJTKHL-UHFFFAOYSA-N InChi: InChI=1S/C17H14N6O4/c18-16-20-14(21-17(22-16)19-12-4-2-1-3-5-12)10-27-15(24)11-6-8-13(9-7-11)23(25)26/h1-9H,10H2,(H3,18,19,20,21,22) Smiles: NC1N=C(NC2C=CC=CC=2)N=C(COC(=O)C2C=CC(=CC=2)[N+]([O-])=O)N=1 Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | TZ9 is a selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B. It binds to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin. It can induce G2/M arrest and apoptosis, and inhibit proliferation and migration of metastatic human breast cancer cells (IC50 ~6 µM). |
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