ML239, Breast Cancer Stem Cell Inhibitor

Overview
Catalog #	bs-60282c-2-mg-solid
Product Name	ML239, Breast Cancer Stem Cell Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 346.6 Formula: C13 H10 Cl3 N3 O2 CAS Number: 1378872-36-6 InChi Key: NVEDPFICKAIHKD-NGYBGAFCSA-N InChi: InChI=1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+ Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	ML239 is a potent and selective breast cancer stem cell inhibitor with IC50 ~1.16 μM. It displayed greater than 23-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_GFP). It did not significantly inhibit tumorsphere formation in the breast cancer cell line SUM159, which is a mixture of CSCs and differentiated cells. ML239 is also cytotoxic towards MDA-MB-231 breast cancer cells.