NI-57, BRPF Bromodomain Inhibitor

Overview
Catalog #	bs-60279c-2-mg-solid
Product Name	NI-57, BRPF Bromodomain Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 383.42 Formula: C19 H17 N3 O4 S CAS Number: 1883548-89-7 InChi Key: UEMQPCYDWCSVCU-UHFFFAOYSA-N InChi: InChI=1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3 Smiles: CC1=CC2=CC(=CC=C2N(C)C1=O)NS(=O)(=O)C1C=CC(=CC=1OC)C#N Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	NI-57 is a potent and selective inhibitor of the bromodomain of the BRPFs. It binds to BRPF1B with a KD of 31 nM (ITC), to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC). NI-57 is very selective against other non-Class IV bromodomains, including the BETs, has minimum 32-fold selectivity against BRD9. It shows accelerated FRAP recovery at 1 µM in the BRPF2 FRAP assay preventing binding of full-length BRPF2 to chromatin.