I-BRD9, Bromodomain Containing Protein 9 (BRD9) Inhibitor

Overview
Catalog #	bs-60276c-2-mg-solid
Product Name	I-BRD9, Bromodomain Containing Protein 9 (BRD9) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 497.55 Formula: C22 H22 F3 N3 O3 S2 CAS Number: 1714146-59-4 InChi Key: WRUWGLUCNBMGPS-UHFFFAOYSA-N InChi: InChI=1S/C22H22F3N3O3S2/c1-2-28-12-17(13-4-3-5-14(10-13)22(23,24)25)19-16(21(28)29)11-18(32-19)20(26)27-15-6-8-33(30,31)9-7-15/h3-5,10-12,15H,2,6-9H2,1H3,(H2,26,27) Smiles: CCN1C=C(C2SC(=CC=2C1=O)C(=N)NC1CCS(=O)(=O)CC1)C1=CC(=CC=C1)C(F)(F)F Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	I-BRD9 is a potent, selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor with Kd ~1.9 nM. It has >700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7). It downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells. I-BRD9 is the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition.