Furamidine dihydrochloride --- PRMT1 Inhibitor
Overview | |
Catalog # | bs-60256c-2mg-solid |
Product Name | Furamidine dihydrochloride --- PRMT1 Inhibitor |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Store in dry, dark place at -20C for 1 year. |
Target | |
Product Information | Molecular Weight: 377.27 Formula: C18 H18 Cl2 N4 O CAS Number: 55368-40-6 InChi Key: VXNYQUQHOUERTR-UHFFFAOYSA-N InChi: InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H Smiles: Cl.Cl.NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N Purity: 98.0 Solubility: DMSO and water up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
Description | Furamidine is a potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor with IC50 of 9.4 µM. It has >10-fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 μM respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions. |