b-AP15 (NSC687852) --- Deubiquitinases Inhibitor

Overview
Catalog #	bs-60251c-2-mg-solid
Product Name	b-AP15 (NSC687852) --- Deubiquitinases Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 419.39 Formula: C22 H17 N3 O6 CAS Number: 1009817-63-3 InChi Key: GFARQYQBWJLZMW-JYFOCSDGSA-N InChi: InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+ Smiles: C=CC(=O)N1C/C(=C\C2C=CC(=CC=2)[N+]([O-])=O)/C(=O)/C(/C1)=C/C1C=CC(=CC=1)[N+]([O-])=O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	b-AP15 (NSC686852) is a potent and selective deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. It inhibits the activity of two 19S regulatory-particle-associated deubiquitinases, UCHL5 and USP14, resulting in accumulation of polyubiquitin. It has minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. b-AP15 induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 ~0.5 μM) and displays antitumor activity in vivo.