HBX41108, USP7 Inhibitor

Overview
Catalog #	bs-60244c-2-mg-solid
Product Name	HBX41108, USP7 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 266.64 Formula: C13 H3 Cl N4 O CAS Number: 924296-39-9 InChi Key: BIGPXXAUSQLTQR-UHFFFAOYSA-N InChi: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H Smiles: N#CC1N=C2C(=NC=1C#N)C(=O)C1C=C(Cl)C=CC=12 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	HBX41108 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM. Kinetics data indicate it is an uncompetitive reversible inhibition mechanism. It inhibits USP7-mediated p53 deubiquitination (IC50 ~0.8 μM). It can also stabilize p53 and activate the transcription of a p53 target gene without inducing genotoxic stress. HBX41108 inhibits cancer cell growth, and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.