INDY --- DYRK1A/B Inhibitor

Overview
Catalog #	bs-60242c-2-mg-solid
Product Name	INDY --- DYRK1A/B Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 235.3 Formula: C12 H13 N O2 S CAS Number: 1169755-45-6 InChi Key: GCSZJMUFYOAHFY-SDQBBNPISA-N InChi: InChI=1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6- Smiles: CC(=O)/C=C1\SC2C=CC(O)=CC=2N\1CC Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	INDY is a potent and selective DYRK1A/B inhibitor with IC50 of 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively. It binds at the ATP-binding cleft of the enzyme, and reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. INDY can impair the self-renewal capacity of subventricular zone neural stem cells. INDY can also induce regeneration and expansion of both rat and adult human beta cells in vivo or ex vivo, and the nuclear factors of activated T cells (NFAT) family of transcription factors are defined as likely mediators of human beta cell proliferation and differentiation.