Azidothymidine (AZT) --- Reverse Transcriptase Inhibitor

Overview
Catalog #	bs-60238c-2-mg-solid
Product Name	Azidothymidine (AZT) --- Reverse Transcriptase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 267.24 Formula: C10 H13 N5 O4 CAS Number: 30516-87-1 InChi Key: HBOMLICNUCNMMY-XLPZGREQSA-N InChi: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1 Smiles: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O Purity: 98.0 Solubility: DMSO up to 100 mM, Water up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Azidothymidine (AZT) is a selective, orally bioavailable and brain penetrant reverse transcriptase inhibitor. It has 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. It can suppress HIV-1 replication and enhance cell viability in a HIV-1 infected T cell line. It can also suppress growth of a multiple myeloma (MM) cell line and reduces the growth of MM tumor xenografts in mice. In recent studies, AZT can enhance CRISPR-mediated sequence-specific gene knockout via NHEJ in human induced pluripotent stem cells (iPSCs) and other cell types.