CAY10603 --- HDAC6 Inhibitor
Overview | |
Catalog # | bs-60234c-2-mg-solid |
Product Name | CAY10603 --- HDAC6 Inhibitor |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Store in dry, dark place at -20C for 1 year. |
Target | |
Product Information | Molecular Weight: 446.5 Formula: C22 H30 N4 O6 CAS Number: 1045792-66-2 InChi Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N InChi: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27) Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C1=CC(=NO1)C(=O)NCCCCCCC(=O)NO Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
Description | CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0.42 nM, 6851 nM, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM. It could be useful chemical probe to study HDAC biology. |