HPOB --- HDAC6 Inhibitor

Overview
Catalog #	bs-60231c-2-mg-solid
Product Name	HPOB --- HDAC6 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 314.34 Formula: C17 H18 N2 O4 CAS Number: 1429651-50-2 InChi Key: RFAZNTABYJYOAR-UHFFFAOYSA-N InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22) Smiles: OCCN(C(=O)CC1C=CC(=CC=1)C(=O)NO)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	HPOB is a potent and selective HDAC6 inhibitor with IC50 of 56 nM. It has >30-fold selectivity over other HDACs. It causes growth inhibition of normal and transformed cells but does not induce cell death. It enhances the effectiveness of DNA-damaging anticancer drugs in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6. In mice bearing CWR22 human prostate cancer xenografts, when in combination with SAHA, HPOB causes suppression of the growth of established tumors, while produces no significant suppression when used alone.