MC1568 --- Class IIa HDAC Inhibitor

Overview
Catalog #	bs-60224c-2-mg-solid
Product Name	MC1568 --- Class IIa HDAC Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 314.31 Formula: C17 H15 F N2 O3 CAS Number: 852475-26-4 InChi Key: QQDIFLSJMFDTCQ-FIFLTTCUSA-N InChi: InChI=1S/C17H15FN2O3/c1-20-14(5-6-15(20)8-10-17(22)19-23)7-9-16(21)12-3-2-4-13(18)11-12/h2-11,23H,1H3,(H,19,22)/b9-7+,10-8+ Smiles: CN1C(C=CC(=O)C2=CC(F)=CC=C2)=CC=C1C=CC(=O)NO Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	MC1568 is a potent and selective inhibitor of class IIa histone deacetylases (HDACs), with IC50 of 100 nM for maize HD1-A. It is 34-fold more selective for HD1-A than HD1-B, 176-fold more selective for class I HDACs. It exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. In a recent study of pancreatic explants, MC1568 enhances expression of Pax4, a key factor required for proper β-and δ-cell differentiation and amplifies endocrine β- and δ-cells.