RVX-208 --- BET Bromodomain Inhibitor
| Overview | |
| Catalog # | bs-60177c-2-mg-solid |
| Product Name | RVX-208 --- BET Bromodomain Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 370.4 Formula: C20 H22 N2 O5 CAS Number: 1044870-39-4 InChi Key: NETXMUIMUZJUTB-UHFFFAOYSA-N InChi: InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24) Smiles: CC1C=C(C=C(C)C=1OCCO)C1NC(=O)C2C(=CC(=CC=2OC)OC)N=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | RVX-208, also known as Apabetalone, is a potent inhibitor of BET bromodomains. RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results in increased HDL-C, but the molecular target was not previously reported. RVX-208 may be a promising new approach to the treatment of atherosclerosis. |
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