LMK235 --- HDAC4 and HDAC5 Inhibitor

Overview
Catalog #	bs-60145c-2mg-solid
Product Name	LMK235 --- HDAC4 and HDAC5 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 294.35 Formula: C15 H22 N2 O4 CAS Number: 1418033-25-6 InChi Key: VRYZCEONIWEUAV-UHFFFAOYSA-N InChi: InChI=1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19) Smiles: CC1=CC(=CC(C)=C1)C(=O)NOCCCCCC(=O)NO Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor (IC50 ~11.9 nM and 4.22 nM respectively). It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC50 for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 ~0.49 and 0.32 μM respectively).