ZLN005 --- PGC-1α Transcriptional Activator
| Overview | |
| Catalog # | bs-60142c-2mg-solid |
| Product Name | ZLN005 --- PGC-1α Transcriptional Activator |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Powder: 4C for 1 year, -20C for 3 years |
| Target | |
| Product Information | Molecular Weight: 250.34 Formula: C17 H18 N2 CAS Number: 49671-76-3 InChi Key: LQUNNCQSFFKSSK-UHFFFAOYSA-N InChi: InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19) Smiles: CC(C)(C)C1C=CC(=CC=1)C1NC2C=CC=CC=2N=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: white to off-white solid powder Shelf Life: 3.0 years |
| Description | ZLN005 is a potent and selective small molecule PGC-1α transcriptional activator. It stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation. Chronic oral administration of ZLN005 at 15 mg/kg per day to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. PGC-1α is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a useful chemical probe to study this target. |
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