SKPin C1 --- Skp2 Inhibitor
| Overview | |
| Catalog # | bs-60137c-2-mg-solid |
| Product Name | SKPin C1 --- Skp2 Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 465.34 Formula: C18 H13 Br N2 O4 S2 CAS Number: 432001-69-9 InChi Key: IYCJJVVXEHZJHE-CHHVJCJISA-N InChi: InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7- Smiles: OC(=O)COC1C=CC(Br)=CC=1/C=C1\SC(=S)N(CC2C=NC=CC=2)C\1=O Purity: 98.0 Solubility: DMSO up to 10 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | SKPin C1 is a potent and selective inhibitor of Skp2-mediated p27 degradation. It selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. In cancer cells, the compounds induced p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. SKPin C1 is a useful chemical probe selectively targeting SCF-Skp2 protein-protein interface, may provide a new avenue of cancer treatment with enhanced specificity over Bortezomib. |
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