Methoxy-X04 --- Fluorescent Amyloid β (Aβ) Probe

Overview
Catalog #	bs-60135c-2-mg-solid
Product Name	Methoxy-X04 --- Fluorescent Amyloid β (Aβ) Probe
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 344.4 Formula: C23 H20 O3 CAS Number: 863918-78-9 InChi Key: FGYNZFHVGOFCMD-KHVHPYDTSA-N InChi: InChI=1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+ Smiles: COC1C=C(/C=C/C2C=CC(O)=CC=2)C=CC=1/C=C/C1C=CC(O)=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Methoxy-X04 is a fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid with good specificity. It is a derivative of Congo red and Chrysamine-G that contains no acid groups and is therefore smaller and much more lipophilic than Congo red or Chrysamine-G. Methoxy-X04 retains in vitro binding affinity for amyloid beta (Abeta) fibrils (Ki = 26.8 nM) very similar to that of Chrysamine-G. Using multiphoton microscopy to obtain high-resolution (1 microm) fluorescent images from the brains of living PSI/APP mice, individual plaques could be distinguished within 30 to 60 min after a single IV injection or a single IP injection of Methoxy-X04.