5-Azacytidine --- DNA Methyltransferase Inhibitor

Overview
Catalog #	bs-60131c-5-mg-solid
Product Name	5-Azacytidine --- DNA Methyltransferase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Powder: 4C for 2 year, -20C for 3 years
Target
Product Information	Molecular Weight: 244.2 Formula: C8 H12 N4 O5 CAS Number: 320-67-2 InChi Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N InChi: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 Smiles: NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O Purity: 98.0 Solubility: H2O : 33.33 mg/mL (136.49 mM; Need ultrasonic); DMSO : ≥ 31 mg/mL (126.95 mM) Appearance: White Solid Powder Shelf Life: 3.0 years
Description	5-Azacytidine is a classic DNA methyltransferase inhibitor. It incorporates into DNA forming covalent adducts with cellular DNMT, depleting enzyme activity. Azacitidine is widely used to demonstrate the correlation between loss of methylation in specific gene regions and activation of the associated genes. It can also improve the efficiency of reprogramming of stem cells, induce differentiation of mesenchymal stem cells into cardiomyocytes.