IWP-2 --- Porcupine (Wnt) Inhibitor
| Overview | |
| Catalog # | bs-60115c-2mg-solid |
| Product Name | IWP-2 --- Porcupine (Wnt) Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 466.6 Formula: C22 H18 N4 O2 S3 CAS Number: 686770-61-6 InChi Key: WRKPZSMRWPJJDH-UHFFFAOYSA-N InChi: InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27) Smiles: CC1=CC2SC(NC(=O)CSC3=NC4CCSC=4C(=O)N3C3C=CC=CC=3)=NC=2C=C1 Purity: 98.0 Solubility: DMSO up to 10 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | IWP-2 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 27 nM in the L-Wnt-STF cellular assay. It prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity. It blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP-2 is a useful chemical probe in both regenerative medicine and anticancer efforts. |
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