WS3 --- β Cell Proliferation Inducer

Overview
Catalog #	bs-60095c-2mg-solid
Product Name	WS3 --- β Cell Proliferation Inducer
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 569.58 Formula: C28 H30 F3 N7 O3 CAS Number: 1421227-52-2 InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N InChi: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39) Smiles: CN1CCN(CC2C=CC(=CC=2C(F)(F)F)NC(=O)NC2C=CC(=CC=2)OC2=CC(NC(=O)C3CC3)=NC=N2)CC1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	WS3 is a highly potent and selective small molecule that promotes pancreatic β cell and RPE cells expansion, identified by a high-throughput, cell-based screening. It can induce proliferation of mouse R7T1 β cells with an EC50 ~0.074 µM, and expansion of primary rat and human β cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments. Furthermore, chemically expanded RPE cells preserve vision when transplanted into dystrophic Royal College of Surgeons (RCS) rats, a well-established model of retinal degeneration.