OAC1 --- Oct4 Activator
Overview | |
Catalog # | bs-60086c-2-mg-solid |
Product Name | OAC1 --- Oct4 Activator |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Store in dry, dark place at -20C for 1 year. |
Target | |
Product Information | Molecular Weight: 237.26 Formula: C14 H11 N3 O CAS Number: 300586-90-7 InChi Key: HWJRIFZDXJKJJN-UHFFFAOYSA-N InChi: InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18) Smiles: O=C(NC1C=C2C=CNC2=CN=1)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
Description | OAC1 is a potent and selective small molecule to activate both Oct4 and Nanog promoter-driven luciferase reporter genes, identified from a cell-based high-throughput screening. When added to the reprogramming media along with the four reprogramming factors (Oct4, Sox2, Klf4, and c-Myc), OAC1 can significantly enhance iPSC reprogramming efficiency (20-fold higher than that induced by the 4F alone) and accelerate the reprogramming process. The iPSC colonies derived using OAC1 along with the four factors exhibited typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency in a unique manner, independent of either inhibition of the p53-p21 pathway or activation of the Wnt-β-catenin signaling. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 may be used for large-scale iPSC generation for various applications. |