SAG --- Hedgehog Agonist
| Overview | |
| Catalog # | bs-60081c-2-mg-solid |
| Product Name | SAG --- Hedgehog Agonist |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Powder: 4C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 490.06 Formula: C28 H28 Cl N3 O S CAS Number: 364590-63-6 InChi Key: VFSUUTYAEQOIMW-YHBQERECSA-N InChi: InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23- Smiles: CN[C@@H]1CC[C@H](CC1)N(CC1C=CC=C(C=1)C1C=CN=CC=1)C(=O)C1SC2=CC=CC=C2C=1Cl Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Powder Solid Shelf Life: 1.0 years |
| Description | SAG is a potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells and counteracts Cyclopamine-KAAD inhibition of Smo. It was reported that SAG acts as an activator at low concentrations and as an inhibitor at high concentrations (>1 µM). In recent studies, SAG was shown to prevent glucocorticoid-induced neonatal cerebellar injury, and trigger rapid metabolic rewiring via AMPK. |
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