LY411575 --- γ-secretase Inhibitor

Overview
Catalog #	bs-60078c-5mg-solid
Product Name	LY411575 --- γ-secretase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 479.48 Formula: C26 H23 F2 N3 O4 CAS Number: 209984-57-6 InChi Key: ULSSJYNJIZWPSB-CVRXJBIPSA-N InChi: InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1 Smiles: C[C@H](NC(=O)[C@@H](O)C1=CC(F)=CC(F)=C1)C(=O)N[C@@H]1C(=O)N(C)C2=CC=CC=C2C2=CC=CC=C21 Purity: 98.0 Solubility: DMSO up to 100mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	LY411575 is a highly potent, selective, and orally bioavailable inhibitor of gamma secretase with an IC50 of ~0.1 nM for APP23 and APP51/16 in primary neurons. It has been shown to promote goblet cell differentiation in mouse intestine. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells. In recent studies, LY411575 increased hair cell number in organ of Corti explants. Systemic LY411575 administration increased hair cell number and promoted hearing recovery in a noise-damaged cochlea, but local LY411575 administration promoted hearing recovery through transdifferentiation of supporting cells into hair cells after noise-induced hearing loss in the mature cochlea.