TMPA---AMPK Activator

Overview
Catalog #	bs-60072c-2-mg-solid
Product Name	TMPA---AMPK Activator
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 380.48 Formula: C21 H32 O6 CAS Number: 1258275-73-8 InChi Key: WCYMJQXRLIDSAQ-UHFFFAOYSA-N InChi: InChI=1S/C21H32O6/c1-6-8-9-10-11-12-17(22)15-13-18(24-3)21(26-5)20(25-4)16(15)14-19(23)27-7-2/h13H,6-12,14H2,1-5H3 Smiles: COC1C(OC)=C(CC(=O)OCC)C(=CC=1OC)C(=O)CCCCCCC Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	TMPA is a novel small molecule that binds to orphan Nuclear Receptor Nur77 with high affinity (Kd = 1.45 ± 0.35 μM), and interferes with the Nur77-LKB1 interaction. TMPA’s binding to Nur77 results in the release and shuttling of LKB1 to the cytoplasm to phosphorylate AMPKα. TMPA treatment can effectively reduce blood glucose and alleviate insulin resistance in type II db/db and high-fat diet– and streptozotocin-induced diabetic mice but not in diabetic littermates with the Nur77 gene knocked out. TMPA may serve as a powerful chemical tool to attain a mechanistic understanding of the regulation of LKB1-AMPK axis and a lead compound for the design and development of therapeutics to treat metabolic diseases.