IDH-C227 --- IDH1 Inhibitor

Overview
Catalog #	bs-60043c-2mg-solid
Product Name	IDH-C227 --- IDH1 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 498.59 Formula: C30 H31 F N4 O2 CAS Number: 1355324-14-9 InChi Key: AATMNHPDEZNXEK-UHFFFAOYSA-N InChi: InChI=1S/C30H31FN4O2/c1-21-8-5-6-13-27(21)29(30(37)34-25-10-3-2-4-11-25)35(26-12-7-9-23(31)18-26)28(36)20-33-24-16-14-22(19-32)15-17-24/h5-9,12-18,25,29,33H,2-4,10-11,20H2,1H3,(H,34,37) Smiles: CC1C=CC=CC=1C(C(=O)NC1CCCCC1)N(C1=CC(F)=CC=C1)C(=O)CNC1C=CC(=CC=1)C#N Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	IDH-C227 is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0.1 µM, and 2-HG production in HT1080 and U87MG cells with IC50 < 0.25 µM. Because the mutated form of IDH1 produces the metabolite, 2-hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of cancer, IDH-C227 serves as a very useful chemical probe to study this novel target.