GDC-0449 (Vismodegib) --- Hedgehog Antagonist
| Overview | |
| Catalog # | bs-60034c-2-mg-solid |
| Product Name | GDC-0449 (Vismodegib) --- Hedgehog Antagonist |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 421.3 Formula: C19 H14 Cl2 N2 O3 S CAS Number: 879085-55-9 InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24) Smiles: CS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC(C2C=CC=CN=2)=C(Cl)C=C1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | Vismodegib (GDC-0449) is a potent and specific hedgehog pathway inhibitor with an IC50 of 3 nM. It has been approved by FDA to treat BCC, and also in multiple clinical trials to treat advanced solid tumors. It blocks the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. It prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 also exhibited efficacy in medulloblastoma animal models and primary pancreatic cancer xenograft models. It was shown to inhibit cell growth in cisplatin-resistant lung cancer cells. |
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