BMS-708163 (Avagacestat) --- γ-Secretase Inhibitor
| Overview | |
| Catalog # | bs-60032c-2-mg-solid |
| Product Name | BMS-708163 (Avagacestat) --- γ-Secretase Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 520.88 Formula: C20 H17 Cl F4 N4 O4 S CAS Number: 1146699-66-2 InChi Key: XEAOPVUAMONVLA-QGZVFWFLSA-N InChi: InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1 Smiles: NC(=O)[C@@H](CCC(F)(F)F)N(CC1C=CC(=CC=1F)C1=NOC=N1)S(=O)(=O)C1C=CC(Cl)=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | BMS-708163 (Avagacestat) is a potent, selective and orally bioavailable γ-secretase inhibitor with an IC50 of 0.3 nM for APP cleavage. It is 190-fold more selective for APP than Notch, having an IC50 of 58 nM for Notch. Phase I clinical trial studies showed that in humans, BMS-708163 decreased CSF Aβ40 and Aβ42 approximately 30% following daily dose of 100 mg after 28 days and by 60% at daily dose of 150 mg. |
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