A769662 --- AMPK Activator
| Overview | |
| Catalog # | bs-60020c-5-mg-solid |
| Product Name | A769662 --- AMPK Activator |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 360.39 Formula: C20 H12 N2 O3 S CAS Number: 844499-71-4 InChi Key: CTESJDQKVOEUOY-UHFFFAOYSA-N InChi: InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) Smiles: N#CC1C(=O)NC2SC=C(C=2C=1O)C1C=CC(=CC=1)C1C=CC=CC=1O Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | A769662 is a potent and selective small-molecule activator of AMP-activated protein kinase (AMPK). It induces allosteric activation of AMPK and inhibition of dephosphorylation of AMPK on Thr-172, similar to the effects of AMP. The activation of AMPK inhibits mTOR signaling, which is a positive effector of cell growth and survival. A769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM. It can also stimulate Na+, K+-ATPase activity in skeletal muscle cells. |
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