SB431542 --- TGF-beta Inhibitor
| Overview | |
| Catalog # | bs-60015c-10mg-solid |
| Product Name | SB431542 --- TGF-beta Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 384.39 Formula: C22 H16 N4 O3 CAS Number: 301836-41-9 InChi Key: FHYUGAJXYORMHI-UHFFFAOYSA-N InChi: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) Smiles: NC(=O)C1C=CC(=CC=1)C1NC(=C(N=1)C1=CC2OCOC=2C=C1)C1C=CC=CN=1 Purity: 98.0 Solubility: DMSO up to 100mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | SB-431542 is a potent and selective inhibitor of TGF-β type I receptors ALK5 (IC50 ~94 nM), ALK4 (IC50 ~140 nM) and ALK7. It has no activities on the other ALK family members such as ALK2, ALK3 and ALK6, nor on components of the ERK, JNK, and p38 MAP kinase pathways. It specifically blocks Smad2 signaling, modulating gene expression related to EMT. In several publications SB-431542 has been used to enhance iPSC reprogramming, induce neural differentiation of human pluripotent stem cells, and promote naïve state of pluripotent stem cells. |
Powered by Bioz