CHIR99021 --- GSK3β Inhibitor
| Overview | |
| Catalog # | bs-60002c-10mg-solid |
| Product Name | CHIR99021 --- GSK3β Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 465.34 Formula: C22 H18 Cl2 N8 CAS Number: 252917-06-9 InChi Key: AQGNHMOJWBZFQQ-UHFFFAOYSA-N InChi: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) Smiles: CC1=CNC(=N1)C1=CN=C(NCCNC2C=CC(=CN=2)C#N)N=C1C1C=CC(Cl)=CC=1Cl Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | CHIR99021 is the most widely used, potent and selective inhibitor of glycogen synthase kinase 3β (GSK3β) with an IC50 ~7 nM. It can effectively activate Wnt signaling pathway in various cellular systems. CHIR99021 has been shown to enhance the reprogramming of murine and human somatic cells into iPSCs, potently promote expansion of embryonic stem cells and tissue-specific adult stem cells (such as hematopoietic stem and progenitor cells, cardiovascular, neural, mammary and intestinal stem cells), and induce differentiation of human ESCs/iPSCs toward neural or mesendoderm lineages under appropriate conditions. |
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