Co-1686

Overview
Catalog #	bs-1110c-2-mg-solid
Product Name	Co-1686
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 555.55 Formula: C27 H28 F3 N7 O3 CAS Number: 1374640-70-6 InChi Key: HUFOZJXAKZVRNJ-UHFFFAOYSA-N InChi: InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35) Smiles: CC(=O)N1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(NC2C=C(C=CC=2)NC(=O)C=C)C(=CN=1)C(F)(F)F Purity: 98.0 Solubility: DMSO: ‚â• 43 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	CO-1686 is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.